Mathematical Modeling with T Cell in Nasofaringeal Carcinoma

Sugiyanto Sugiyanto, Meksianis Zadrak Ndii


Nasopharyngeal carcinoma triggered by Ebstein Barr virus is a cancer of the first malignancy in the head and neck, which is located in nasopharynx, behind the nose. Cupping and habbatussauda consumption is a process of detoxification of toxins in the body so as immunity increases. Prophet Muhammad delivered quite a lot about cupping and habbatussauda consumption. In this paper, we employ the mathematical model approach to understand nasopharyngeal carcinoma cell level. The formulated mathematical models focus on two cases. First, it is focused on modelling low immunity without cupping and habbatussauda consumption, and second, it is focused on modelling low immunity with the cupping and habbatussauda consumption. In this research, we focus on the second one as the first one has been conducted previously. The model consists of eight sub-populations which are normal cells, lesion cells, low dysplastic cells, the infected cells, high dysplastic cells, invansive carcinoma cells, viruses, and T cells. In this second case, increasing T cell hamper invansive carcinoma because characteristic T cell kill abnormal cells.


nasopharyngeal carcinoma; cupping; habbatussauda; mathematical modeling; Ebstein-Barr Virus; T cell

Full Text:



Aryati, L., Adi-Kusumo, F., & Hardianti, M. S. (2016). A Cellular Mathematical Model of Nasopharyngeal Carcinoma with Addition Compartment of Virus. Far East Journal of Mathematical Sciences, 100(8), 1289.

Michaela S. & Natalie M., 2015, Genetically modified T cells in cancer therapy: opportunities and challenges, The Company of Biologists Ltd | Disease Models & Mechanisms (2015) 8, 337-350 doi:10.1242/dmm.018036.

Pederson, J. E., & Anderson, D. R. (1980). The mode of progressive disc cupping in ocular hypertension and glaucoma. Archives of ophthalmology, 98(3), 490-495.

Randhawa, Mohammad Akram, and Mastour Safar Alghamdi. "Anticancer activity of Nigella sativa (black seed)—a review." The American journal of Chinese medicine 39.06 (2011): 1075-1091.

Straathof, K. C., Bollard, C. M., Popat, U., Huls, M. H., Lopez, T., Morriss, M. C., ... & Rooney, C. M. (2005). Treatment of nasopharyngeal carcinoma with Epstein-Barr virus–specific T lymphocytes. Blood, 105(5), 1898-1904.

Sugiyanto, Adi-Kusumo, F., Aryati, L., & Hardianti, M. S. (2014, February). Mathematical modeling of nasopharynx carcinoma on cell level. In AIP Conference Proceedings (Vol. 1587, No. 1, pp. 88-91). AIP.


  • There are currently no refbacks.

Copyright (c) 2019 Kaunia: Integration and Interconnection Islam and Science

Copyright © 2016 Kaunia: Integration and Interconnection Islam and Science
ISSN 1829-5266 (print) | ISSN 2301-8550 (online)
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License