Analysis of Modification in Synaptic Plasticity STDP (Spike Timing Dependent Plasticity) Model by Changing Intracellular Calcium Concentration

Authors

  • Shella Aisiyah Diva UIN Sunan Kalijaga
  • Anis Yuniati UIN Sunan Kalijaga

DOI:

https://doi.org/10.14421/kaunia.2160

Keywords:

intracellular calcium, LTD, LTP, STDP, synaptic plasticity

Abstract

Synapses are a junction between neurons that has a plastic property. Synaptic plasticity can be in the form of long-term potentiation (LTP) and long-term depression (LTD). The changes in intracellular calcium concentration can trigger LTP and LTD. Spike Timing Dependent Plasticity (STDP) is a modification of synapses that depend on the spike timing of pre-synapses and post-synapses neuron. In this study, we analyze the effects of intracellular calcium on the STDP phenomena based on Badoual’s model using mechanisms involving parameters such as calcium pumping, AMPA receptors, NMDA receptors, LTP enzymes, and LTD enzymes. In this model, a high calcium concentration will activate the LTP enzyme, while a low calcium concentration will activate the LTD enzyme, each of which will trigger the occurrence of LTP and LTD. The existence of LTP and LTD is the basis for the formation of the STDP. In this model, the parameters can be adjusted to obtain the STDP corresponding to experimental results where LTP is observed in the range between 0 < ∆t < 50ms, while LTD is observed at wider intervals between −150ms < ∆t <0. These parameters are related to the decay time of the NMDA receptor.

References

Abarbanel, H. D. I., Huerta, R., & Rabinovich, M. I. (2002). Dynamical model of long-term synaptic plasticity. Proceedings of the National Academy of Sciences of the United States of America, 99(15), 10132–10137. https://doi.org/10.1073/pnas.132651299

Approach, D., Absence, I. N., Epileptic, V., With, S., & Seizure, A. (2014). PENDEKATAN DIAGNOSIS BANGKITAN ABSANS DAN. 31(4).

Badoual, M., Zou, Q., Davison, A. P., Rudolph, M., Bal, T., Frégnac, Y., & Destexhe, A. (2006). Biophysical and phenomenological models of multiple spike interactions in spike-timing dependent plasticity. International Journal of Neural Systems, 16(2), 79–97. https://doi.org/10.1142/S0129065706000524

Barker-Haliski, M., & Steve White, H. (2015). Glutamatergic mechanisms associated with seizures and epilepsy. Cold Spring Harbor Perspectives in Medicine, 5(8), 1–15. https://doi.org/10.1101/cshperspect.a022863

Bonansco, C., & Fuenzalida, M. (2016). Plasticity of hippocampal excitatory-inhibitory balance: Missing the synaptic control in the epileptic brain. Neural Plasticity, 2016. https://doi.org/10.1155/2016/8607038

Caporale, N., & Dan, Y. (2008). Spike Timing–Dependent Plasticity: A Hebbian Learning Rule. Annual Review of Neuroscience, 31(1), 25–46. https://doi.org/10.1146/annurev.neuro.31.060407.125639

Cooper, A. F., & Thakur, R. (2013). The group of twenty (G20). In The Group of Twenty (G20) (pp. 1–194). https://doi.org/10.4324/9780203071236

Cummings, J. A., Mulkey, R. M., Nicoll, R. A., & Malenka, R. C. (1996). Ca2+ signaling requirements for long-term depression in the hippocampus. Neuron, 16(4), 825–833. https://doi.org/10.1016/S0896-6273(00)80102-6

Destexhe, A, Mainen, Z. F., & Sejnowski, T. J. (1994). Destexhe Mainen Sejnowski 1994. 3–6.

Destexhe, Alain, Mainen, Z. F., & Sejnowski, T. J. (1998). Kinetic models of synaptic transmission. Methods in Neuronal Modeling, January 1998, 1–25. http://cns.iaf.cnrs-gif.fr/abstracts/KSchap96.html

Gardette, R., Debono, M., Dupont, J. L., & Crepel, F. (1985). Electrophysiological studies on the postnatal development of intracerebellar nuclei neurons in rat cerebellar slices maintained in vitro. II. Membrane conductances. Developmental Brain Research, 20(1), 97–106. https://doi.org/10.1016/0165-3806(85)90091-4

Göl, M. F., Erdoğan, F. F., Bayramov, K. K., Mehmetbeyoğlu, E., & Özkul, Y. (2019). Assessment of genes involved in behavior, learning, memory, and synaptic plasticity following status epilepticus in rats. Epilepsy and Behavior, 98, 101–109. https://doi.org/10.1016/j.yebeh.2019.06.023

Goldman, B. Y. D. E. (1943). IN MEMBRANES ( From the Department of ] Physiology , College of Physicians and Surgeons , Columbia University , New York ). 37–60.

Guli, X., Tokay, T., Kirschstein, T., & Köhling, R. (2016). Status Epilepticus Enhances Depotentiation after Fully Established LTP in an NMDAR-Dependent but GluN2B-Independent Manner. Neural Plasticity, 2016(1). https://doi.org/10.1155/2016/6592038

Han, T., Qin, Y., Mou, C., Wang, M., Jiang, M., & Liu, B. (2016). SZ induced synaptic plasticity alternation in hippo is mediated by IL-1B receptor throtugh PI3K-Akt pathway 2016 Han Liu AmJTranslRes. 8(10), 4499–4509.

Harris, K. M. (1994). Harris_1994_DS_Flexibility.

Hines, M. L., & Carnevale, N. T. (1997). The NEURON Simulation Environment. Neural Computation, 9(6), 1179–1209. https://doi.org/10.1162/neco.1997.9.6.1179

Holthoff, K., & Tsay, D. (2002). Dynamic Confocal Imaging of Living Brain Calcium dynamics in spines : link to synaptic plasticity Experimental Physiology : Experimental Physiology : Experimental Physiology, 87(6), 725--731.

Husna, M., & Kurniawan, S. N. (2018). Mekanisme Kerja Obat Anti Epilepsi Secara Biomolekuler. Mnj, 4(3), 38–45.

Jahr, C. E., & Stevens, C. F. (1990). Voltage Dependence of NMDA-Activated Predicted by Single-Channel Kinetics. Journal of Neuroscience, 10(9), 3178–3182.

Jarero-Basulto, J. J., Gasca-Martínez, Y., Rivera-Cervantes, M. C., Ureña-Guerrero, M. E., Feria-Velasco, A. I., & Beas-Zarate, C. (2018). Interactions between epilepsy and plasticity. Pharmaceuticals, 11(1), 1–18. https://doi.org/10.3390/ph11010017

Karmarkar, U. R., & Buonomano, D. V. (2002). A model of spike-timing dependent plasticity: One or two coincidence detectors? Journal of Neurophysiology, 88(1), 507–513. https://doi.org/10.1152/jn.2002.88.1.507

Kesahihan, U. J. I., & Keandalan, D. A. N. (2015). ( Qolie-31 ) Versi Bahasa Indonesia Validation and Reliability Test of the Indonesian Version of. 32(3).

Kryukov, K. A., Kim, K. K., Magazanik, L. G., & Zaitsev, A. V. (2016). Status epilepticus alters hippocampal long-term synaptic potentiation in a rat lithium-pilocarpine model. NeuroReport, 27(16), 1191–1195. https://doi.org/10.1097/WNR.0000000000000656

Kubena, K. S. (1994). The role of magnesium in immunity. Journal of Nutritional Immunology, 2(3), 107–126. https://doi.org/10.1300/J053v02n03_07

Kurniawan, S. N. (2015a). INTRACELLULAR Ca2+ HOMEOSTASIS. MNJ (Malang Neurology Journal), 1(1), 36–45. https://doi.org/10.21776/ub.mnj.2015.001.01.7

Kurniawan, S. N. (2015b). Sinyal Neuron Neuronal Signaling. 1(2), 86–96. https://doi.org/10.21776

Kurniawan, S. N., Utomo, D. H., Rudijanto, A., Rahayu, M., & Aulanni’am, A. (2018). Nuclear Factor Erythroid 2 activation mediated by PRKCA in increasing Ca2+ intracellular in diabetic condition. International Journal Bioautomation, 22(2), 159–168. https://doi.org/10.7546/ijba.2018.22.2.159-168

Lestari, N. D., Mutiawati, E., Rahmawati, E., Octaviana, F., & Bachtiar, A. (2017). Analisis Properti Psikometri Internalized Stigma of Epilepsy Versi Indonesia. 34(2).

Levy, W. B. (1983). in the Hippocampus. Neuroscience, 8(4).

Lisman, J. (1989). A mechanism for the Hebb and the anti-Hebb processes underlying learning and memory. Proceedings of the National Academy of Sciences of the United States of America, 86(23), 9574–9578. https://doi.org/10.1073/pnas.86.23.9574

Lisman, John. (1985). A mechanism for memory storage insensitive to molecular turnover. Proceedings of the National Academy of Sciences of the United States of America, 82(May), 3055–3057. https://www.pnas.org/content/pnas/82/9/3055.full.pdf

Lynch, G., Larson, J., Kelso, S., Barrionuevo, G., & Schottler, F. (1983). Intracellular injections of EGTA block induction of hippocampal long-term potentiation. Nature, 305(5936), 719–721. https://doi.org/10.1038/305719a0

Magee, J. C., & Johnston, D. (1997). A synaptically controlled, associative signal for Hebbian plasticity in hippocampal neurons. Science, 275(5297), 209–213. https://doi.org/10.1126/science.275.5297.209

Malenka, R. C., Kauer, J. A., Zucker, R. S., & Nicoll, R. A. (1988). Postsynaptic calcium is sufficient for potentiation of hippocampal synaptic transmission. Science, 242(4875), 81–84. https://doi.org/10.1126/science.2845577

Meric-Bernstam, F., & Mills, G. B. (2004). Mammalian target of rapamycin. Seminars in Oncology, 31(SUPPL. 16), 10–17. https://doi.org/10.1053/j.seminoncol.2004.10.013

Of, C., Mri, Q., Magnetization, I., Ratio, T., Intelligence, W., In, Q., Temporal, M., & Epilepsy, L. (2015). KORELASI MAGNETIZATION TRANSFER RATIO INTERIKTAL DENGAN INTELLIGENCE QUOTIENT PADA EPILEPSI LOBUS TEMPORAL MESIAL RESISTEN OBAT TRANSFER RATIO WITH INTELLIGENCE QUOTIENT IN DRUG-RESISTANT. 32(2).

Parameswaran, S., Vijayamma, A. K. T., & Pillai, A. M. (2019). Efficacy of Short Term Video Eeg in Detecting Psychogenic Non-Epileptic Seizures. MNJ (Malang Neurology Journal), 5(2), 65–67. https://doi.org/10.21776/ub.mnj.2019.005.02.3

Perea, G., Gómez, R., Mederos, S., Covelo, A., Ballesteros, J. J., Schlosser, L., Hernández-Vivanco, A., Martín-Fernández, M., Quintana, R., Rayan, A., Díez, A., Fuenzalida, M., Agarwal, A., Bergles, D. E., Bettler, B., Manahan-Vaughan, D., Martín, E. D., Kirchhoff, F., & Araque, A. (2016). Activity-dependent switch of gabaergic inhibition into glutamatergic excitation in astrocyte-neuron networks. ELife, 5(DECEMBER2016), 1–26. https://doi.org/10.7554/eLife.20362

Plasticity, A., Dentate, O. F. A., In, C., Model, A. R. A. T., Mesial, O. F., & Lobe, T. (2017). CELLS IN A RAT MODEL OF MESIAL TEMPORAL LOBE. 734, 187–196. https://doi.org/10.1016/j.nbd.2015.11.024.AXONAL

Postnikova, T. Yu, Trofimova, A. M., Zaitsev, A. V., & Magazanik, L. G. (2017). Status epilepticus induced by pentylenetetrazole increases short-term synaptic facilitation in the hippocampus of juvenile rats. Doklady Biological Sciences, 477(1), 207–209. https://doi.org/10.1134/S0012496617060102

Postnikova, T Y, Zubareva, O. E., Kovalenko, A. A., Kim, K. K., Magazanik, L. G., & Zaitsev, A. V. (2017). Epileptic seizures in patients with temporal. 82(3), 282–290. https://doi.org/10.1134/S0006297917030063

Pramesti, F. A., Husna, M., Kurniawan, S. N., Rahayu, M., Neurologi, L., Kedokteran, F., & Brawijaya, U. (2017). Diagnosis and Management of Nonconvulsive Status Epilepticus (NCSE). Diagnosis and Management of Nonconvulsive Status Epilepticus (NCSE), Vol.03, No, 30–38.

Rubin, J. E., Gerkin, R. C., Bi, G. Q., & Chow, C. C. (2005). Calcium time course as a signal for spike-timing-dependent plasticity. Journal of Neurophysiology, 93(5), 2600–2613. https://doi.org/10.1152/jn.00803.2004

Sabatini, B. L., Oertner, T. G., & Svoboda, K. (2002). The life cycle of Ca2+ ions in dendritic spines. Neuron, 33(3), 439–452. https://doi.org/10.1016/S0896-6273(02)00573-1

Shouval, H. Z., Bear, M. F., & Cooper, L. N. (2002). A unified model of NMDA receptor-dependent bidirectional synaptic plasticity. Proceedings of the National Academy of Sciences of the United States of America, 99(16), 10831–10836. https://doi.org/10.1073/pnas.152343099

Sjöström, J., & Gerstner, W. (2010). {S}pike-timing dependent plasticity. Scholarpedia, 5(2), 1362. https://doi.org/10.4249/scholarpedia.1362

Song, S., Miller, K. D., & Abbott, L. F. (2000). Competitive Hebbian learning through spike-timing-dependent synaptic plasticity. Nature Neuroscience, 3(9), 919–926. https://doi.org/10.1038/78829

Spannow, K. E. (1998). Research Article. Nordic Studies on Alcohol and Drugs, 15(1), 3–4. https://doi.org/10.1177/145507259801500104

Zahra, F. A., Islamiyah, W. R., & Budiono, B. (2019). Profile of Subjective Sleep Disturbance in Patient With Antiepileptic Drugs. MNJ (Malang Neurology Journal), 5(2), 61–64. https://doi.org/10.21776/ub.mnj.2019.005.02.2

Zubareva, O. E., Kovalenko, A. A., Karyakin, V. B., Kalemenev, S. V., Lavrent’eva, V. V., Magazanik, L. G., & Zaitsev, A. V. (2018). Changes in the Expression of Genes of the Glutamate Transporter and Subunits of the NMDA and AMPA Receptors in the Rat Amygdala in the Lithium–Pilocarpine Model of Epilepsy. Neurochemical Journal, 12(3), 222–227. https://doi.org/10.1134/s1819712418030170

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Published

2020-10-30

How to Cite

Diva, S. A., & Yuniati, A. (2020). Analysis of Modification in Synaptic Plasticity STDP (Spike Timing Dependent Plasticity) Model by Changing Intracellular Calcium Concentration. Kaunia: Integration and Interconnection Islam and Science Journal, 16(2), 29–35. https://doi.org/10.14421/kaunia.2160

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Vol. 16 No. 2 (2020)

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